Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.45 |
| ▸ | PRKCG | P05129 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | AKT2 | P31751 | 2/20 | 0.45 |
| ▸ | MATK | P42679 | 2/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.45 |
| ▸ | BLK | P51451 | 2/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13056839 | 0.88 | PARP1 (0.68) | PARP1AURKBTP53CDC7PLK4 | |
| SCHEMBL3335735 | 0.88 | PARP1 (0.59) | PARP1AURKBTP53CDC7PLK4 | |
| SCHEMBL3338380 | 0.83 | PARP1 (0.54) | PARP1AURKBTP53CDC7PLK4 | |
| SCHEMBL31500071 | 0.83 | PARP1 (0.54) | PARP1AURKBTP53CDC7PLK4 | |
| SCHEMBL3336562 | 0.78 | PARP1 (0.69) | PARP1TP53KDM4EALDH1A1BRPF1 | |
| SCHEMBL2429766 | 0.77 | PARP1 (0.65) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL22046017 | 0.77 | TP53 (0.77) | PARP1AURKBTP53CDC7PLK4 | |
| SCHEMBL9415645 | 0.77 | PARP1 (0.65) | PARP1AURKBTP53CDC7PLK4 | |
| SCHEMBL29673202 | 0.77 | PARP1 (0.65) | PARP1AURKBTP53CDC7PLK4 | |
| SCHEMBL9415611 | 0.77 | PARP1 (0.65) | PARP1AURKBTP53CDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152180-A1 | 4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152180-A1 | 4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | PARP1, PARP2, PARP4 | PARP1 1/4885AURKB 1008/4885TP53 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.