Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 15/20 | 0.62 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303619 | 0.81 | ADORA2A (0.60) | ADORA2AADORA1 | |
| SCHEMBL2301144 | 0.81 | ADORA2A (0.58) | ADORA2AADORA1 | |
| SCHEMBL3302518 | 0.81 | ADORA2A (0.62) | ADORA2AADORA1 | |
| SCHEMBL3302521 | 0.81 | ADORA2A (0.62) | ADORA2AADORA1 | |
| SCHEMBL3301961 | 0.78 | ADORA2A (0.65) | ADORA2AADORA1 | |
| SCHEMBL3301964 | 0.78 | ADORA2A (0.65) | ADORA2AADORA1 | |
| SCHEMBL3300401 | 0.76 | ADORA2A (1.00) | ADORA2AADORA1 | |
| SCHEMBL3303145 | 0.76 | ADORA2A (1.00) | ADORA2AADORA1 | |
| SCHEMBL3346316 | 0.76 | ADORA2A (0.82) | ADORA2AADORA1 | |
| SCHEMBL3303514 | 0.76 | ADORA2A (1.00) | ADORA2AADORA1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045009-A1 | PHENYL AND HETEROARYL SUBSTITUTED THIENO[2,3-d] PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-22 | — | — | WO | disclosed |