Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.79 |
| ▸ | CDK2 | P24941 | 7/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.68 |
| ▸ | INSR | P06213 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313416 | 0.92 | IGF1R (0.81) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3345458 | 0.90 | IGF1R (0.79) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3313628 | 0.88 | IGF1R (1.00) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3315074 | 0.87 | IGF1R (0.83) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3313812 | 0.84 | IGF1R (0.69) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3312137 | 0.83 | IGF1R (0.86) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3314795 | 0.83 | IGF1R (0.81) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3316846 | 0.83 | IGF1R (0.86) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3352092 | 0.82 | IGF1R (0.67) | IGF1RCDK2KCNH2INSR | |
| SCHEMBL3315961 | 0.82 | IGF1R (0.83) | IGF1RCDK2KCNH2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | claimed |
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |