Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 20/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 19/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.56 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.56 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376458 | 0.82 | PIK3CG (0.82) | PIK3CGPIK3CDPIK3CBPIK3CAPAK4 | |
| SCHEMBL3346340 | 0.81 | PIK3CG (0.70) | PIK3CGPIK3CDPIK3CBPIK3CAPAK4 | |
| SCHEMBL3346291 | 0.80 | PIK3CG (0.80) | PIK3CGPIK3CDPIK3CBPIK3CAPAK4 | |
| SCHEMBL3353512 | 0.80 | PIK3CG (0.81) | PIK3CGPIK3CDPIK3CBPIK3CAPAK4 | |
| SCHEMBL3378682 | 0.79 | PIK3CG (0.67) | PIK3CGPIK3CDPIK3CBPIK3CAPAK4 | |
| SCHEMBL3351142 | 0.76 | PIK3CG (0.82) | PIK3CGPIK3CDPIK3CBPIK3CAPAK4 | |
| SCHEMBL3346521 | 0.74 | PIK3CG (0.59) | PIK3CGPIK3CDPIK3CBPIK3CAPAK4 | |
| SCHEMBL3346756 | 0.73 | PIK3CG (0.56) | PIK3CGPIK3CDPIK3CBPIK3CAPAK4 | |
| SCHEMBL9276725 | 0.73 | PIK3CG (0.83) | PIK3CGPIK3CDPIK3CBPIK3CA | |
| SCHEMBL2783009 | 0.73 | PIK3CG (0.84) | PIK3CGPIK3CDPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057877-A1 | 7-PYRIDINYL- OR PHENYL- SUBSTITUTED TRIAZOLO [1, 5 -A] PYRIDINES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057877-A1 | 7-PYRIDINYL- OR PHENYL- SUBSTITUTED TRIAZOLO [1, 5 -A] PYRIDINES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2010-05-27 | — | — | WO | disclosed |