Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.75 |
| ▸ | NTRK1 | P04629 | 12/20 | 0.60 |
| ▸ | IGF1R | P08069 | 5/20 | 0.59 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FER | P16591 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | STAT5A | P42229 | 1/20 | 0.53 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2634640 | 0.89 | NTRK1 (0.77) | JAK2NTRK1IGF1RJAK3 | |
| SCHEMBL217071 | 0.86 | JAK2 (1.00) | JAK2NTRK1IGF1RJAK3AURKA | |
| SCHEMBL217828 | 0.84 | JAK2 (0.82) | JAK2NTRK1IGF1RJAK3AURKA | |
| SCHEMBL4072757 | 0.80 | NTRK1 (0.74) | NTRK1IGF1R | |
| SCHEMBL22535810 | 0.80 | JAK2 (0.75) | JAK2NTRK1IGF1RJAK3AURKA | |
| SCHEMBL22535307 | 0.78 | JAK2 (0.71) | JAK2NTRK1IGF1RJAK3AURKA | |
| SCHEMBL22535278 | 0.78 | JAK2 (0.71) | JAK2NTRK1IGF1RJAK3AURKA | |
| SCHEMBL22535636 | 0.77 | JAK2 (0.69) | JAK2NTRK1IGF1RJAK3AURKA | |
| SCHEMBL56620 | 0.76 | IGF1R (0.69) | NTRK1IGF1R | |
| SCHEMBL22535325 | 0.75 | JAK2 (0.67) | JAK2NTRK1IGF1RJAK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160325-A1 | 4-(3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2010-06-24 | — | — | US | disclosed |
| US-20080287475-A1 | 4-(3-Aminopyrazole) Pyrimidine Derivatives for Use as Tyrosine Kinase Inhibitors in the Treatment of Cancer | ASTRAZENECA AB (SE) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287475-A1 | 4-(3-Aminopyrazole) Pyrimidine Derivatives for Use as Tyrosine Kinase Inhibitors in the Treatment of Cancer | ABL1, FLT3, ERBB2 | JAK2 35/4885NTRK1 759/4885IGF1R 818/4885 |
| US-20100160325-A1 | 4-(3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER | ABL1, FLT3, ERBB2 | JAK2 35/4885NTRK1 759/4885IGF1R 818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.