Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.51 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.47 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346230 | 0.87 | KCNQ3 (0.66) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL13365126 | 0.85 | KCNH2 (0.52) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL13364979 | 0.85 | KCNH2 (0.58) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3412005 | 0.84 | KCNH2 (0.55) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3346539 | 0.84 | KCNH2 (0.57) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3346373 | 0.84 | KCNH2 (0.57) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3346676 | 0.83 | KCNQ3 (0.53) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3353138 | 0.83 | KCNQ3 (0.52) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL13365070 | 0.82 | KCNH2 (0.55) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3346485 | 0.82 | KCNH2 (0.63) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |