Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.51 |
| ▸ | ACLY | P53396 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13363241 | 0.83 | NR4A2 (0.58) | NR4A2NPC1MAPTKDM4EHDAC1 | |
| SCHEMBL4652841 | 0.82 | PTPN1 (0.51) | TNFRSF1AACLYKDM4EHDAC1HDAC2 | |
| SCHEMBL20235825 | 0.81 | NR4A2 (0.60) | NR4A2KMT2AMEN1NPC1MAPT | |
| SCHEMBL21798966 | 0.80 | HDAC1 (0.59) | NR4A2NPC1MAPTKDM4EHDAC1 | |
| SCHEMBL4685813 | 0.80 | NR4A2 (0.62) | NR4A2TNFRSF1AKMT2AMEN1KDM4E | |
| SCHEMBL4225433 | 0.80 | NR4A2 (0.50) | NR4A2TNFRSF1AACLYKMT2AMAPT | |
| SCHEMBL27272859 | 0.79 | HDAC4 (0.42) | NR4A2NPC1L3MBTL1RAB9AHDAC4 | |
| SCHEMBL30987649 | 0.79 | HDAC4 (0.42) | NR4A2NPC1L3MBTL1RAB9AHDAC4 | |
| SCHEMBL10331368 | 0.78 | HPGD (0.41) | NR4A2KMT2AMEN1NPC1MAPT | |
| SCHEMBL4651623 | 0.77 | NR4A2 (0.55) | NR4A2ACLYKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057899-A1 | CYCLOALKYL AMINO CARBONYL DERIVATIVES AS BRADYKININ-B1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-27 | — | — | WO | disclosed |