Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.44 |
| ▸ | BCL6 | P41182 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351030 | 0.83 | SYK (0.59) | EGFRERBB2HPGDHTTAURKA | |
| SCHEMBL3449008 | 0.81 | FLT3 (0.48) | EGFRERBB2HPGDHTTSTK17A | |
| SCHEMBL3449012 | 0.81 | FLT3 (0.48) | EGFRERBB2HPGDHTTSTK17A | |
| SCHEMBL3450155 | 0.78 | SELP (0.48) | EGFRERBB2HPGDHTTAXL | |
| SCHEMBL3447819 | 0.78 | SELP (0.48) | EGFRERBB2HPGDHTTAXL | |
| SCHEMBL3449528 | 0.78 | SELP (0.48) | EGFRERBB2HPGDHTTAXL | |
| SCHEMBL3344593 | 0.74 | STK17A (0.60) | AXLSTK17ASTK17BSYKULK1 | |
| SCHEMBL3375644 | 0.72 | STK17A (0.56) | AXLSTK17ASTK17BSYKINSR | |
| SCHEMBL3449683 | 0.72 | AXL (0.62) | EGFRAXLSTK17ASTK17B | |
| SCHEMBL3449182 | 0.72 | STK17A (0.52) | EGFRAXLSTK17ASTK17BULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |