Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3320612 | 0.85 | MAPT (0.59) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL3324257 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL31442541 | 0.82 | SMN1; SMN2 (0.71) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL10256511 | 0.82 | SMN1; SMN2 (0.71) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL3316435 | 0.78 | MAPT (0.58) | SMN1; SMN2KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL26617708 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL3319109 | 0.76 | MEN1 (0.75) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL31442663 | 0.76 | MEN1 (0.75) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL7248226 | 0.74 | KDM4E (0.70) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL1468948 | 0.74 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056865-A1 | QUINOLINE DERIVATIVES AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | WO | claimed |