Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345762 | 0.94 | MAPK14 (0.47) | MAPK14MAPK11ROCK2ROCK1TP53 | |
| SCHEMBL3352426 | 0.92 | MAPK14 (0.49) | MAPK14MAPK11ROCK2ROCK1TP53 | |
| SCHEMBL3347486 | 0.92 | MAPT (0.45) | MAPK14MCHR1MAPK11ROCK2ROCK1 | |
| SCHEMBL3318484 | 0.92 | MAPK14 (0.44) | MAPK14MAPK11ROCK2ROCK1TP53 | |
| SCHEMBL3345794 | 0.90 | MAPK14 (0.53) | MAPK14MAPK11TP53MAPT | |
| SCHEMBL3317134 | 0.89 | MAPK14 (0.49) | MAPK14MAPK11TP53MAPTPOLB | |
| SCHEMBL3345530 | 0.89 | MAPK14 (0.42) | MAPK14MAPK11ROCK2ROCK1TP53 | |
| SCHEMBL3349382 | 0.88 | MAPK14 (0.55) | MAPK14MAPK11ROCK2ROCK1TP53 | |
| SCHEMBL27635999 | 0.88 | MAPK14 (0.50) | MAPK14MAPK11ROCK2ROCK1TP53 | |
| SCHEMBL3594171 | 0.88 | MAPK14 (0.47) | MAPK14MAPK11ROCK2ROCK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652044-B2 | P-38 inhibitors | NOVARTIS A.G. (CH) | 2010-01-26 | — | — | US | claimed |