SCHEMBL33533424

SCHEMBL33533424

COc1cc(-c2cn(C)c(=O)c(C)c2C)cc(OC)c1CN1CC2CCC(C1)N2C(=O)OC(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 6/20 0.49
BRD9 Q9H8M2 5/20 0.49
BRD2 P25440 3/20 0.49
BRD7 Q9NPI1 3/20 0.49
CYP3A4 P08684 1/20 0.40
KCNK3 O14649 4/20 0.39
KCNK9 Q9NPC2 4/20 0.39
CD274 Q9NZQ7 6/20 0.38
RET P07949 1/20 0.36
HSD11B1 P28845 1/20 0.35
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL33533254 0.95 BRD9 (0.49) BRD4BRD9BRD2BRD7CYP3A4
SCHEMBL33533083 0.91 BRD9 (0.51) BRD4BRD9BRD2BRD7CYP3A4
SCHEMBL23783302 0.86 BRD4 (0.49) BRD4BRD9BRD2BRD7CYP3A4
SCHEMBL33532825 0.84 BRD9 (0.48) BRD4BRD9BRD2BRD7CYP3A4
SCHEMBL33533012 0.84 BRD9 (0.54) BRD9BRD7CYP3A4
SCHEMBL33530765 0.84 BRD9 (0.49) BRD4BRD9BRD2BRD7CYP3A4
SCHEMBL23783038 0.83 BRD4 (0.53) BRD4BRD9BRD2BRD7CYP3A4
SCHEMBL33531804 0.83 BRD9 (0.48) BRD4BRD9BRD2BRD7CYP3A4
SCHEMBL33532700 0.83 BRD9 (0.48) BRD4BRD9BRD2BRD7CYP3A4
SCHEMBL30297131 0.83 BRD4 (0.51) BRD4BRD9BRD2BRD7CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092061-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION AMPHISTA THERAPEUTICS LTD (GB) 2026-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092061-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION BCL9L, RBBP9, BRD9 BRD4 161/4885BRD9 3/4885BRD2 34/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.