Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16473721 | 1.00 | KDM1A (0.44) | KDM1AFFAR1SIGMAR1NR1H2NR1H3 | |
| SCHEMBL12389149 | 0.91 | KDM1A (0.49) | KDM1AFFAR1NR1H2NR1H3LMNA | |
| SCHEMBL2311267 | 0.87 | FFAR1 (0.42) | KDM1AFFAR1SIGMAR1NR1H2NR1H3 | |
| SCHEMBL2312379 | 0.87 | FFAR1 (0.42) | KDM1AFFAR1SIGMAR1NR1H2NR1H3 | |
| SCHEMBL2313463 | 0.87 | FFAR1 (0.42) | KDM1AFFAR1SIGMAR1NR1H2NR1H3 | |
| SCHEMBL2313640 | 0.87 | FFAR1 (0.42) | KDM1AFFAR1SIGMAR1NR1H2NR1H3 | |
| SCHEMBL2312767 | 0.87 | FFAR1 (0.42) | KDM1AFFAR1SIGMAR1NR1H2NR1H3 | |
| SCHEMBL17988204 | 0.84 | KDM1A (0.62) | KDM1AFFAR1 | |
| SCHEMBL30015902 | 0.84 | KDM1A (0.50) | KDM1AFFAR1 | |
| SCHEMBL17988190 | 0.84 | KDM1A (0.62) | KDM1AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045258-A2 | SPIROCYCLIC GPR40 MODULATORS | AMGEN INC. (US) | 2010-04-22 | — | — | WO | disclosed |