Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 14/20 | 0.78 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.45 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045774 | 0.89 | ZAP70 (0.75) | ZAP70JAK2TTBK1TTBK2SYK | |
| SCHEMBL1047738 | 0.88 | ZAP70 (1.00) | ZAP70JAK2TTBK1TTBK2SYK | |
| SCHEMBL1049167 | 0.88 | ZAP70 (0.68) | ZAP70JAK2ADORA3SYK | |
| SCHEMBL1048961 | 0.87 | ZAP70 (0.69) | ZAP70JAK2ADORA3SYK | |
| SCHEMBL1045093 | 0.86 | ZAP70 (0.72) | ZAP70JAK2TTBK1TTBK2SYK | |
| SCHEMBL1158186 | 0.83 | ZAP70 (0.69) | ZAP70JAK2TTBK1TTBK2SYK | |
| SCHEMBL1049032 | 0.83 | ZAP70 (0.72) | ZAP70JAK2TTBK1TTBK2SYK | |
| SCHEMBL1158001 | 0.82 | ZAP70 (0.64) | ZAP70JAK2TTBK1TTBK2 | |
| SCHEMBL1158422 | 0.82 | ZAP70 (0.64) | ZAP70JAK2TTBK1TTBK2SYK | |
| SCHEMBL1045837 | 0.82 | ZAP70 (0.67) | ZAP70JAK2SYKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |