Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 7/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CES2 | O00748 | 4/20 | 0.56 |
| ▸ | CES1 | P23141 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dodecanoate SCHEMBL5518529 | 0.96 | CA1 (0.67) | FABP3CA1CES2CES1NFKB1 | |
| Stearic Acid SCHEMBL10488860 | 0.96 | FABP3 (0.62) | FABP3CA1CES2CES1NFKB1 | |
| Stearic Acid SCHEMBL27580087 | 0.96 | CA1 (0.67) | FABP3CA1CES2CES1NFKB1 | |
| Myristic Acid SCHEMBL27863287 | 0.96 | CA1 (0.67) | FABP3CA1CES2CES1NFKB1 | |
| Undecanoate SCHEMBL28955047 | 0.94 | FABP3 (0.60) | FABP3CA1CES2CES1NFKB1 | |
| Dodecanoate SCHEMBL28376091 | 0.94 | FABP3 (0.60) | FABP3CA1CES2CES1NFKB1 | |
| Stearic Acid SCHEMBL3357535 | 0.94 | FABP3 (0.60) | FABP3CA1CES2CES1NFKB1 | |
| Dodecanoate SCHEMBL8140299 | 0.91 | FABP3 (0.62) | FABP3CA1CES2CES1NFKB1 | |
| Nonadecanoic Acid SCHEMBL11324237 | 0.91 | FABP3 (0.72) | FABP3CA1CES2CES1NFKB1 | |
| Heptanoate SCHEMBL3789493 | 0.91 | FABP3 (0.72) | FABP3CA1CES2CES1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1752148-B1 | Substituted phenethylsulfones for the treatment of inflammatory, infectious, immunological or malignant disease | CELGENE CORP (US) | 2010-06-23 | — | — | EP | disclosed |