Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.49 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.49 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357550 | 1.00 | MEN1 (0.56) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3349573 | 0.93 | MEN1 (0.53) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL13166032 | 0.93 | MEN1 (0.53) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3349576 | 0.93 | MEN1 (0.53) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL4602979 | 0.92 | MEN1 (0.56) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL13166294 | 0.91 | MEN1 (0.55) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3357612 | 0.91 | MEN1 (0.55) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3352208 | 0.91 | MEN1 (0.53) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3352218 | 0.91 | MEN1 (0.53) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3353582 | 0.90 | MEN1 (0.55) | MEN1KMT2AGAAPOLBMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803945-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-09-28 | — | — | US | claimed |
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| US-7803945-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-09-28 | — | — | US | disclosed |
| US-7723523-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-25 | — | — | US | disclosed |
| US-20090270378-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2009-10-29 | — | — | US | disclosed |
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| US-20070244112-A1 | Novel tetrahydropyridothiophenes | ALTANA PHARMA AG (DE) | 2007-10-18 | — | — | US | disclosed |
| EP-1753512-A2 | TETRAHYDROPYRIDOTHIOPHENES | Altana Pharma AG (DE) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118071-A2 | TETRAHYDROPYRIDOTHIOPHENES | ALTANA PHARMA AG (DE) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270378-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | BAX, BCL2, CCAR2 | MEN1 4646/4885KMT2A 2220/4885GAA 4376/4885 |
| US-20070244112-A1 | Novel tetrahydropyridothiophenes | BAX, BCL2, BAD | MEN1 4610/4885KMT2A 2358/4885GAA 4265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.