Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 14/20 | 0.60 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1158081 | 0.93 | ZAP70 (0.63) | ZAP70JAK2JAK1SYK | |
| SCHEMBL1158463 | 0.91 | ZAP70 (0.60) | ZAP70JAK2JAK1SYK | |
| SCHEMBL1043540 | 0.90 | ZAP70 (0.74) | ZAP70JAK2JAK1SYK | |
| SCHEMBL1047940 | 0.89 | ZAP70 (0.68) | ZAP70SYK | |
| SCHEMBL1158037 | 0.89 | ZAP70 (0.58) | ZAP70JAK2JAK1SYK | |
| SCHEMBL1048440 | 0.89 | ZAP70 (0.60) | ZAP70SYK | |
| SCHEMBL1159147 | 0.87 | ZAP70 (0.72) | ZAP70JAK2JAK1SYK | |
| SCHEMBL1158545 | 0.86 | ZAP70 (0.56) | ZAP70JAK2JAK1 | |
| SCHEMBL1047586 | 0.86 | ZAP70 (0.80) | ZAP70SYK | |
| SCHEMBL1048484 | 0.85 | ZAP70 (0.64) | ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| CN-101990539-A | Compounds and compositions as kinase inhibitors | IRM LLC | 2011-03-23 | — | — | CN | disclosed |