⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22176939 | 1.00 | — | — | |
| SCHEMBL22176658 | 1.00 | — | — | |
| SCHEMBL18207791 | 0.93 | GRIN1 (0.36) | — | |
| SCHEMBL3928323 | 0.88 | CHRM2 (0.34) | — | |
| SCHEMBL19937579 | 0.88 | CHRM2 (0.34) | — | |
| SCHEMBL27589544 | 0.86 | GRIN1 (0.35) | — | |
| SCHEMBL16993648 | 0.85 | — | — | |
| SCHEMBL16993647 | 0.85 | — | — | |
| SCHEMBL1794650 | 0.85 | — | — | |
| SCHEMBL24702209 | 0.84 | GRIN1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067939-B1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG PROTEIN SIGNALING PATHWAYS | UNIV JOHNS HOPKINS (US) | 2015-09-16 | — | — | EP | claimed |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2008-03-06 | — | — | US | claimed |
| US-7291626-B1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2007-11-06 | — | — | US | claimed |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-06-29 | — | — | US | claimed |
| US-20060020020-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2006-01-26 | — | — | US | claimed |
| US-20040127474-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2004-07-01 | — | — | US | claimed |
| US-6432970-B2 | REDUCE CELL SENSITIVITY | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2002-08-13 | — | — | US | claimed |
| JP-2002511415-A | — | — | 2002-04-16 | — | — | JP | claimed |
| US-20020006931-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | THE JOHNS HOPKINS UNIVERSITY | 2002-01-17 | — | — | US | claimed |
| US-20010034337-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. | 2001-10-25 | — | — | US | claimed |
| EP-1143961-A2 | REGULATORS OF THE PTC OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | Ontogeny, Inc. (US) | 2001-10-17 | — | — | EP | claimed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | claimed |
| WO-2000041545-A2 | REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 2000-07-20 | — | — | WO | claimed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | claimed |
| US-20250304563-A1 | ACTIVATORS OF EFFECTOR T CELLS | ORUM THERAPEUTICS, INC. (KR) | 2025-10-02 | — | — | US | disclosed |
| EP-4490152-A1 | ACTIVATORS OF EFFECTOR T CELLS | Orum Therapeutics Inc. (KR) | 2025-01-15 | — | — | EP | disclosed |
| WO-2023170608-A1 | ACTIVATORS OF EFFECTOR T CELLS | ORUM THERAPEUTICS, INC. (KR) | 2023-09-14 | — | — | WO | disclosed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-2000041545-A2 | REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 2000-07-20 | — | — | WO | disclosed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | disclosed |