⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004026 | 0.93 | — | — | |
| SCHEMBL50123 | 0.93 | — | — | |
| SCHEMBL6694270 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL3362939 | 0.86 | — | — | |
| SCHEMBL11520211 | 0.86 | — | — | |
| Ammonia Solution, Strong SCHEMBL11409106 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL11274092 | 0.86 | — | — | |
| Fluoride SCHEMBL34460639 | 0.86 | — | — | |
| SCHEMBL31239165 | 0.86 | — | — | |
| Ethylene SCHEMBL9752325 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150258092-A1 | RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS | YALE UNIVERSITY (US) | 2015-09-17 | — | — | US | disclosed |
| US-8912150-B2 | Ribosome structure and protein synthesis inhibitors | MELINTA THERAPEUTICS, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-20140066623-A1 | Ribosome Structure and Protein Synthesis Inhibitors | MELINTA THERAPEUTICS, LLC | 2014-03-06 | — | — | US | disclosed |
| EP-1308457-B1 | Ribosome structure and protein synthesis inhibitors | UNIV YALE (US) | 2013-12-04 | — | — | EP | disclosed |
| US-8470990-B2 | Ribosome structure and protein synthesis inhibitors | RIB-X PHARMACEUTICALS, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100312525-A1 | Ribosome Structure and Protein Synthesis Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-09 | — | — | US | disclosed |
| US-20100204253-A1 | Ribosome Structure and Protein Synthesis Inhibitors | YALE UNIVERSITY (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100131258-A1 | Method for identifying protein synthesis inhibitors by ribosome structure | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-05-27 | — | — | US | disclosed |
| US-7666849-B2 | ligands that are designed to specifically kill or inhibit the growth of any target organism | RIB-X PHARMACEUTICALS, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-7504486-B2 | Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes | YALE UNIVERSITY (US) | 2009-03-17 | — | — | US | disclosed |
| US-6947845-B2 | Method of identifying molecules that bind to the large ribosomal subunit | YALE UNIVERSITY (US) | 2005-09-20 | — | — | US | disclosed |
| US-6939848-B2 | Crystals of the large ribosomal subunit | YALE UNIVERSITY (US) | 2005-09-06 | — | — | US | disclosed |
| US-20050036997-A1 | Molecular modeling of the binding sites for anisomycin, azithromycin, erythromycin, linezolid, tylosin, carbomycin A, spiramycin, virginiamycin, sparsomycin and blasticidin using the Haloarcular marismortui large ribosomal subunit; drug design and drug screening | YALE UNIVERSITY (US) | 2005-02-17 | — | — | US | disclosed |
| US-20030232779-A1 | Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes | MELINTA SUBSIDIARY CORP. (F/K/A MELINTA THERAPEUTICS, INC.) | 2003-12-18 | — | — | US | disclosed |
| US-6638908-B1 | High resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution determining the | YALE UNIVERSITY | 2003-10-28 | — | — | US | disclosed |
| US-20030171327-A1 | Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes | MELINTA SUBSIDIARY CORP. (F/K/A MELINTA THERAPEUTICS, INC.) | 2003-09-11 | — | — | US | disclosed |
| US-20030153002-A1 | Ribosome structure and protein synthesis inhibitors | MELINTA SUBSIDIARY CORP. | 2003-08-14 | — | — | US | disclosed |
| EP-1308457-A1 | Ribosome structure and protein synthesis inhibitors | YALE UNIVERSITY (US) | 2003-05-07 | — | — | EP | disclosed |
| US-20020086308-A1 | Ribosome structure and protein synthesis inhibitors | MELINTA SUBSIDIARY CORP. (F/K/A MELINTA THERAPEUTICS, INC.) | 2002-07-04 | — | — | US | disclosed |
| EP-1188769-A2 | High resolution crystal structure of the ribosome and design of protein synthesis inhibitors | YALE UNIVERSITY (US) | 2002-03-20 | — | — | EP | disclosed |