Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 10/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662028 | 0.88 | JAK2 (0.59) | PDPK1JAK2CHEK1CDK2GSK3A | |
| SCHEMBL29489772 | 0.76 | GPR17 (0.53) | CHEK1CDK2GSK3AGSK3BKCNH2 | |
| SCHEMBL2239471 | 0.76 | GPR17 (0.53) | CHEK1CDK2GSK3AGSK3BKCNH2 | |
| SCHEMBL6487382 | 0.76 | PDPK1 (0.55) | PDPK1JAK2CHEK1CDK2AURKA | |
| SCHEMBL12907241 | 0.75 | JAK2 (1.00) | PDPK1JAK2CHEK1CDK2GSK3A | |
| SCHEMBL3361070 | 0.75 | JAK2 (1.00) | PDPK1JAK2CHEK1CDK2GSK3A | |
| SCHEMBL4487628 | 0.74 | GSK3B (0.72) | CDK2GSK3AGSK3BFGFR4 | |
| SCHEMBL6485242 | 0.73 | PDPK1 (1.00) | PDPK1JAK2CHEK1CDK2GSK3B | |
| SCHEMBL4489337 | 0.73 | PDPK1 (0.64) | PDPK1JAK2CHEK1CDK2GSK3A | |
| SCHEMBL12907202 | 0.73 | PDPK1 (0.69) | PDPK1JAK2CDK2GSK3BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638941-B1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LAB (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2003051847-A1 | (1-H-INDAZOL-3-YL) -AMIDE DERIVATIVES AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-26 | — | — | WO | disclosed |