Prednisolone Hemisuccinate

Prednisolone Hemisuccinate

SCHEMBL3360749

C[C@]12C=CC(=O)C=C1CC[C@@H]1C3CC[C@](O)(C(=O)COC(=O)CCC(=O)O)[C@@]3(C)CC(O)[C@H]12.[NaH]

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.84
LMNA P02545 2/20 0.84
PGR P06401 4/20 0.79
NR3C1 P04150 8/20 0.74
SMN1; SMN2 Q16637 2/20 0.72
KMT2A Q03164 1/20 0.72
CYP3A4 P08684 3/20 0.71
HSD17B10 Q99714 2/20 0.71
AR P10275 2/20 0.71
ABCB11 O95342 1/20 0.71
TNF P01375 1/20 0.71
IL6 P05231 1/20 0.71
SERPINA6 P08185 1/20 0.71
NR3C2 P08235 1/20 0.71
GLUL P15104 1/20 0.71
ADAM17 P78536 1/20 0.71
GPBAR1 Q8TDU6 1/20 0.71
CYP2C19 P33261 1/20 0.71
USP2 O75604 1/20 0.61
CYP2D6 P10635 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Prednisolone Hemisuccinate SCHEMBL27639542 1.00 HIF1A (0.84) HIF1ALMNAPGRNR3C1SMN1; SMN2
Prednisolone Hemisuccinate SCHEMBL12540510 0.99 HIF1A (0.85) HIF1ALMNAPGRNR3C1SMN1; SMN2
Prednisolone Hemisuccinate SCHEMBL16009511 0.99 HIF1A (0.85) HIF1ALMNAPGRNR3C1SMN1; SMN2
Prednisolone Hemisuccinate SCHEMBL139689 0.99 HIF1A (0.85) HIF1ALMNAPGRNR3C1SMN1; SMN2
Prednisolone Hemisuccinate SCHEMBL13026153 0.99 HIF1A (0.85) HIF1ALMNAPGRNR3C1SMN1; SMN2
Prednisolone Hemisuccinate SCHEMBL25138782 0.99 HIF1A (0.85) HIF1ALMNAPGRNR3C1SMN1; SMN2
Prednisolone Hemisuccinate SCHEMBL945987 0.99 HIF1A (0.85) HIF1ALMNAPGRNR3C1SMN1; SMN2
Prednisolone Hemisuccinate SCHEMBL7155955 0.98 HIF1A (0.84) HIF1ALMNAPGRNR3C1SMN1; SMN2
SCHEMBL16009510 0.96 HIF1A (0.91) HIF1ALMNAPGRNR3C1SMN1; SMN2
SCHEMBL16170220 0.93 HIF1A (0.85) HIF1ALMNAPGRNR3C1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10182993-B2 Compositions for colonic delivery of drugs PATHEON SOFTGELS INC. (US) 2019-01-22 US disclosed
EP-3086789-A1 OPIOID ANTAGONIST FORMULATIONS Purdue Pharma L.P. (US) 2016-11-02 EP disclosed
US-20160287525-A1 COMPOSITIONS FOR COLONIC DELIVERY OF DRUGS BANNER LIFE SCIENCES LLC 2016-10-06 US disclosed
US-20160243107-A1 Opioid Antagonist Formulations PURDUE PHARMA L.P. 2016-08-25 US disclosed
WO-2015100197-A1 OPIOID ANTAGONIST FORMULATIONS PURDUE PHARMA L.P. (US) 2015-07-02 WO disclosed
US-20100209520-A1 ORAL PHARMACEUTICAL PREPARATION FOR COLON-SPECIFIC DELIVERY AMATERASPHARMA INC. (JP) 2010-08-19 US disclosed
EP-2143424-A1 ORAL PHARMACEUTICAL PREPARATION FOR COLON-SPECIFIC DELIVERY TEIKOKU SEIYAKU CO., LTD. (JP) 2010-01-13 EP disclosed