Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 2/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | GPR183 | P32249 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361973 | 0.80 | ZAP70 (0.47) | LRRK2ZAP70SYKTYK2 | |
| SCHEMBL1049202 | 0.79 | ZAP70 (0.61) | LRRK2ZAP70BTKKCNH2SYK | |
| SCHEMBL3362641 | 0.79 | PIK3CA (0.38) | BTKKCNH2SYKPIK3CASMO | |
| SCHEMBL3357809 | 0.77 | SYK (0.44) | ZAP70BTKKCNH2SYKPIK3CA | |
| SCHEMBL3359856 | 0.76 | ZAP70 (0.40) | ZAP70SYKPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3360026 | 0.76 | SYK (0.46) | LRRK2ZAP70BTKKCNH2SYK | |
| SCHEMBL3358811 | 0.76 | SYK (0.46) | LRRK2ZAP70BTKKCNH2SYK | |
| SCHEMBL3362887 | 0.75 | ZAP70 (0.46) | ZAP70BTKSYK | |
| SCHEMBL3361678 | 0.75 | ZAP70 (0.42) | ZAP70SYK | |
| SCHEMBL3359641 | 0.75 | ZAP70 (0.41) | ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |