Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 14/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360687 | 0.88 | ZAP70 (0.47) | ZAP70MAP4K1BRD4 | |
| SCHEMBL3363124 | 0.87 | ZAP70 (0.46) | ZAP70MAP4K1BRD4 | |
| SCHEMBL3362296 | 0.87 | ZAP70 (0.49) | ZAP70MAP4K1BRD4 | |
| SCHEMBL3363125 | 0.86 | ZAP70 (0.49) | ZAP70MAP4K1BRD4 | |
| SCHEMBL3362467 | 0.86 | ZAP70 (0.49) | ZAP70MAP4K1BRD4 | |
| SCHEMBL3362632 | 0.85 | ZAP70 (0.45) | ZAP70SYKMAP4K1BRD4 | |
| SCHEMBL3357921 | 0.85 | ZAP70 (0.47) | ZAP70MAP4K1BRD4 | |
| SCHEMBL3358764 | 0.82 | SYK (0.42) | ZAP70SYKBRD4 | |
| SCHEMBL3358746 | 0.81 | ZAP70 (0.43) | ZAP70MAP4K1WEE1BRD4 | |
| SCHEMBL3359888 | 0.81 | ZAP70 (0.41) | ZAP70SYKMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |