Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 11/20 | 0.83 |
| ▸ | HTT | P42858 | 1/20 | 0.97 |
| ▸ | BCHE | P06276 | 13/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2206818 | 1.00 | HTT (0.97) | HTTBCHEACHE | |
| Lauryl Isoquinolinium SCHEMBL324418 | 1.00 | HTT (0.97) | HTTBCHEACHE | |
| Bromide SCHEMBL1961820 | 1.00 | HTT (0.97) | HTTBCHEACHE | |
| Lauryl Isoquinolinium SCHEMBL29453824 | 1.00 | HTT (0.97) | HTTBCHEACHE | |
| Bromide SCHEMBL3363615 | 1.00 | HTT (0.97) | HTTBCHEACHE | |
| SCHEMBL1963054 | 0.98 | HTT (1.00) | HTTBCHEACHE | |
| SCHEMBL9512245 | 0.98 | HTT (1.00) | HTTBCHEACHE | |
| Bromide SCHEMBL3726903 | 0.98 | HTT (0.93) | HTTBCHEACHE | |
| SCHEMBL1412713 | 0.98 | HTT (1.00) | HTTBCHEACHE | |
| SCHEMBL3902995 | 0.98 | HTT (1.00) | HTTBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367358-B2 | Reagent, kit and method for differentiating and counting leukocytes | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2013-02-05 | — | — | US | claimed |
| US-20100151509-A1 | REAGENT, KIT AND METHOD FOR DIFFERENTATING AND COUNTING LEUKOCYTES | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2010-06-17 | — | — | US | claimed |
| US-8367358-B2 | Reagent, kit and method for differentiating and counting leukocytes | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2013-02-05 | — | — | US | disclosed |
| US-20100151509-A1 | REAGENT, KIT AND METHOD FOR DIFFERENTATING AND COUNTING LEUKOCYTES | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2010-06-17 | — | — | US | disclosed |