Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.67 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.67 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363065 | 1.00 | PIM1 (0.67) | PIM1PIM2FLT3PIM3PIK3CG | |
| SCHEMBL12990510 | 1.00 | PIM1 (0.67) | PIM1PIM2FLT3PIM3PIK3CG | |
| SCHEMBL3425697 | 0.89 | PIM1 (0.53) | PIM1PIM2FLT3PIM3GSK3A | |
| SCHEMBL3425692 | 0.89 | PIM1 (0.53) | PIM1PIM2FLT3PIM3GSK3A | |
| SCHEMBL12990207 | 0.89 | PIM1 (0.53) | PIM1PIM2FLT3PIM3GSK3A | |
| SCHEMBL3363068 | 0.88 | PIM1 (0.64) | PIM1PIM2FLT3PIM3PIK3CG | |
| SCHEMBL12990513 | 0.86 | PIM1 (0.67) | PIM1PIM2FLT3PIM3PIK3CG | |
| SCHEMBL3363071 | 0.86 | PIM1 (0.67) | PIM1PIM2FLT3PIM3PIK3CG | |
| SCHEMBL3363075 | 0.86 | PIM1 (0.67) | PIM1PIM2FLT3PIM3PIK3CG | |
| SCHEMBL3363324 | 0.85 | PIM1 (0.66) | PIM1PIM2FLT3PIM3PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331315-A1 | RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS | SENHWA BIOSCIENCES, INC. (TW) | 2010-12-30 | — | — | US | disclosed |
| WO-2010148351-A1 | RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331315-A1 | RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS | PIM2, PIM1, CDK2 | PIM1 2/4885PIM2 1/4885FLT3 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.