Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 20/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 18/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365270 | 0.95 | HCRTR1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL3361629 | 0.94 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL3365184 | 0.93 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL3365648 | 0.92 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3363390 | 0.92 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3362052 | 0.91 | HCRTR1 (0.43) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3362997 | 0.87 | HCRTR1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL3363447 | 0.84 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL3365410 | 0.84 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3361861 | 0.84 | HCRTR1 (0.47) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155739-B1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-10-06 | — | — | EP | claimed |