Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 17/20 | 0.56 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363257 | 0.97 | HCRTR1 (0.59) | HCRTR1HCRTR2 | |
| SCHEMBL3363286 | 0.87 | HCRTR1 (0.53) | HCRTR1HCRTR2 | |
| SCHEMBL3053180 | 0.85 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL3050213 | 0.85 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL3363252 | 0.84 | HCRTR1 (0.56) | HCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL3059256 | 0.84 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL3059254 | 0.84 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL3038243 | 0.82 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL3364004 | 0.82 | HCRTR1 (0.51) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL3361876 | 0.81 | HCRTR1 (0.49) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155739-B1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-10-06 | — | — | EP | claimed |