⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505223 | 0.82 | — | — | |
| SCHEMBL12816642 | 0.80 | — | — | |
| SCHEMBL3191508 | 0.77 | — | — | |
| SCHEMBL2346875 | 0.71 | — | — | |
| SCHEMBL5160170 | 0.66 | — | — | |
| SCHEMBL12817083 | 0.61 | — | — | |
| SCHEMBL16797719 | 0.59 | — | — | |
| SCHEMBL5433560 | 0.57 | — | — | |
| SCHEMBL1032769 | 0.56 | — | — | |
| SCHEMBL1593092 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 463 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018170067-A1 | SMALL MOLECULE SENSITIZATION OF BAX ACTIVATION FOR INDUCTION OF CELL DEATH | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-09-20 | — | — | WO | claimed |
| US-9688645-B2 | Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa | SANOFI (FR) | 2017-06-27 | — | — | US | claimed |
| US-20160251324-A1 | MACROCYCLIC UREA AND SULFAMIDE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI-AVENTIS (FR) | 2016-09-01 | — | — | US | claimed |
| EP-2226319-B1 | Process for the preparation of 2-(2-aminopyrimidin-4-yl)-1H-indol-5-carbonic acid derivatives | SANOFI SA (FR) | 2016-03-16 | — | — | EP | claimed |
| EP-2240486-B1 | TRIAZOLIUM SALTS AS PAR1 INHIBITORS, THEIR MANUFACTURE AND THEIR APPLICATION AS MEDICINE | SANOFI SA (FR) | 2015-09-09 | — | — | EP | claimed |
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | claimed |
| EP-2104497-B1 | SULFAMIDE DERIVATIVES AS TAFIA INHIBITORS | SANOFI SA (FR) | 2015-02-25 | — | — | EP | claimed |
| EP-2558465-B1 | TRICYCLIC PYRIDYL-VINYL-PYROLES AS PAR1 INHIBITORS | SANOFI SA (FR) | 2014-12-17 | — | — | EP | claimed |
| US-8871798-B2 | Tricyclic pyridyl-vinyl pyrroles as PAR1 inhibitors | SANOFI (FR) | 2014-10-28 | — | — | US | claimed |
| US-8853206-B2 | Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments | SANOFI (FR) | 2014-10-07 | — | — | US | claimed |
| WO-2006077013-A1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI-AVENTIS (DE) | 2006-07-27 | — | — | WO | claimed |
| EP-1670766-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | Sanofi-Aventis Deutschland GmbH (DE) | 2006-06-21 | — | — | EP | claimed |
| WO-2006002764-A1 | 4-TRIFLUOROMETHOXYPHENOXYBENZOL-4'-SULFONIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF IN MEDICAMENTS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | claimed |
| EP-1585728-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | Aventis Pharma Deutschland GmbH (DE) | 2005-10-19 | — | — | EP | claimed |
| WO-2005073236-A2 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | WO | claimed |
| US-20050080127-A1 | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-04-14 | — | — | US | claimed |
| WO-2005030728-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-04-07 | — | — | WO | claimed |
| US-20050004166-A1 | Imino acid derivatives as inhibitors of matrix metalloproteinases | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-06 | — | — | US | claimed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | claimed |
| US-6646010-B2 | Enzyme inhibitors such as N(3-benzyloxycarbonylamino-2-hydroxy -4-phenylbutyl)-N-isoamylamine, used for prophylaxis of viral diseases and infections; lymphadenopathy associated virus | G. D. SEARLE & CO. | 2003-11-11 | — | — | US | claimed |