Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437393 | 0.87 | SLC6A4 (0.50) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2437392 | 0.87 | SLC6A4 (0.50) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2432542 | 0.86 | SLC6A4 (0.55) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2432539 | 0.86 | SLC6A4 (0.55) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2436544 | 0.81 | POLB (0.49) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2436547 | 0.81 | POLB (0.49) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL20953933 | 0.79 | SLC6A4 (0.48) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2433059 | 0.79 | SLC6A4 (0.48) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2435068 | 0.79 | SLC6A4 (0.48) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2433062 | 0.79 | SLC6A4 (0.48) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011302-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2010-01-28 | — | — | WO | claimed |
| WO-2010011302-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2010-01-28 | — | — | WO | disclosed |