⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1158769 | 0.92 | PPARA (0.58) | — | |
| SCHEMBL11221936 | 0.90 | PPARA (0.61) | — | |
| SCHEMBL10930258 | 0.90 | PPARA (0.61) | — | |
| SCHEMBL1111454 | 0.83 | — | — | |
| Butyl(Butylsulfamoyl)Amine SCHEMBL2486301 | 0.78 | CA1 (1.00) | — | |
| SCHEMBL245387 | 0.78 | — | — | |
| SCHEMBL2111624 | 0.76 | — | — | |
| SCHEMBL8679104 | 0.76 | CA1 (0.67) | — | |
| SCHEMBL277303 | 0.76 | CA1 (0.67) | — | |
| SCHEMBL487521 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |
| EP-1797077-A4 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF I | ASTRAZENECA AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| EP-1311475-B1 | AMINOCYCLOHEXANE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-08-06 | — | — | EP | disclosed |
| US-7335687-B2 | 2,3-Oxidosqualene-lanosterol cyclase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2008-02-26 | — | — | US | disclosed |
| EP-1797077-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF I | AstraZeneca AB (SE) | 2007-06-20 | — | — | EP | disclosed |
| EP-1778654-A1 | SULFAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR UPREGULATION OF LIPID METABOLISM COMPRISING SAME | Crystalgenomics, Inc. (KR) | 2007-05-02 | — | — | EP | disclosed |
| US-7202258-B2 | α- and β-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7189756-B2 | Pyrrolidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7102007-B2 | Dihydroindole and tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-09-05 | — | — | US | disclosed |
| US-7071212-B2 | N-(4-carbamimidoyl-phenyl)-glycine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-4704388-A | ANTIULCER, CYTOPROTECTIVE | RORER PHARMACEUTICAL CORPORATION (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0185684-A4 | 3- AND 5- ADBICYCLIC ETHER OR BICYCLIC ALKYLENE THIOETHER BDALKYLENE AMINO THIATRIAZINES, AND THEIR PHARMACEUTICAL USES. | RORER INTERNAT OVERSEAS INC (US) | 1986-09-22 | — | — | EP | disclosed |
| EP-0185684-A1 | 3- AND 5- ADBICYCLIC ETHER OR BICYCLIC ALKYLENE THIOETHER BDALKYLENE AMINO THIATRIAZINES, AND THEIR PHARMACEUTICAL USES | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1986-07-02 | — | — | EP | disclosed |
| WO-1985005105-A1 | 3- AND 5- ADBICYCLIC ETHER OR BICYCLIC ALKYLENE THIOETHER BDALKYLENE AMINO THIATRIAZINES, AND THEIR PHARMACEUTICAL USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1985-11-21 | — | — | WO | disclosed |
| US-4327034-A | CHEMICAL INTERMEDIATE PREPARED FROM A SULFAMIC ACID HALIDE AND A HALOGEN COMPOUND | BASF AKTIENGESELLSCHAFT (DE) | 1982-04-27 | — | — | US | disclosed |
| EP-0009054-A1 | N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same | MERCK & CO. INC. (US) | 1980-04-02 | — | — | EP | disclosed |
| US-4115573-A | N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidine and processes for preparing same | MERCK & CO., INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4096181-A | Substituted sulfamic acid halides | BASF AKTIENGESELLSCHAFT (DT) | 1978-06-20 | — | — | US | disclosed |
| US-3992444-A | BY REACTION OF A SULFAMIC ACID WITH AN ACID HALIDE | BASF AKTIENGESELLSCHAFT (DT) | 1976-11-16 | — | — | US | disclosed |
| US-3935201-A | Production of 2,1,3-benzothiadiazin-4-one-2,2-dioxides | BASF AKTIENGESELLSCHAFT (DT) | 1976-01-27 | — | — | US | disclosed |