Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365889 | 1.00 | HPGD (0.68) | HPGDPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3365742 | 1.00 | HPGD (0.68) | HPGDPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3368692 | 0.92 | HPGD (0.60) | HPGDPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3368700 | 0.92 | HPGD (0.60) | HPGDPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3365526 | 0.91 | ATM (0.61) | HPGDPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3365519 | 0.91 | ATM (0.61) | HPGDPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3365233 | 0.91 | ATM (0.61) | HPGDPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3368001 | 0.89 | HPGD (0.61) | HPGDPOLBMEN1KMT2ATSHR | |
| SCHEMBL3367994 | 0.89 | HPGD (0.61) | HPGDPOLBMEN1KMT2ATSHR | |
| SCHEMBL3367277 | 0.88 | HPGD (0.70) | HPGDPOLBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542969-B1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-03-03 | — | — | EP | claimed |
| WO-2006138475-A2 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2006-12-28 | — | — | WO | disclosed |