Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 15/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365379 | 0.91 | LSS (0.64) | LSSMEN1KMT2A | |
| SCHEMBL3364637 | 0.91 | LSS (0.64) | LSSMEN1KMT2A | |
| SCHEMBL3365325 | 0.90 | LSS (0.78) | LSSMEN1KMT2A | |
| SCHEMBL3363133 | 0.90 | LSS (0.78) | LSSMEN1KMT2A | |
| SCHEMBL3365279 | 0.90 | LSS (0.63) | LSSMEN1KMT2A | |
| SCHEMBL3366763 | 0.90 | LSS (0.76) | LSSMEN1KMT2A | |
| SCHEMBL3368382 | 0.89 | LSS (0.59) | LSSMAOBGAAMEN1KMT2A | |
| SCHEMBL3368467 | 0.88 | LSS (0.61) | LSSMEN1KMT2A | |
| SCHEMBL3366804 | 0.87 | LSS (0.57) | LSSMAOBGAAMEN1KMT2A | |
| SCHEMBL3365180 | 0.87 | LSS (0.80) | LSSGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |
| US-6683201-B2 | FOR THERAPY AND PROPHYLAXIS OF HYPERCHOLESTEROLEMIA, HYPERLIPEMIA, ARTERIOSCLEROSIS, VASCULAR DISEASES, MYCOSES, PARASITE INFECTIONS, GALLSTONES, TUMORS AND/OR HYPERPROLIFERATIVE DISORDERS, DIABETES | HOFFMANN-LA ROCHE INC. | 2004-01-27 | — | — | US | disclosed |
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |