Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341356 | 1.00 | TP53 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL8022118 | 0.97 | — | — | |
| SCHEMBL26999467 | 0.97 | — | — | |
| SCHEMBL26999468 | 0.97 | — | — | |
| SCHEMBL8019227 | 0.92 | — | — | |
| Cyclopropylcarboxaldehyde SCHEMBL367544 | 0.86 | — | — | |
| SCHEMBL5186842 | 0.78 | TP53 (0.44) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL5186833 | 0.78 | TP53 (0.44) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL5188226 | 0.78 | TP53 (0.44) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL5188231 | 0.78 | TP53 (0.44) | TP53KDM4EGMNNLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179600-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AS INHIBITORS OF ASK1 | Hepagene Therapeutics (HK) Limited (HK) | 2021-06-17 | — | — | US | disclosed |
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
| US-20080318947-A1 | Inhibitors of Akt Activity | HEERDING DIRK A | 2008-12-25 | — | — | US | disclosed |
| US-20080200467-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. | 2008-08-21 | — | — | US | disclosed |
| EP-0505089-B1 | A catalyst for asymmetric induction | SUMITOMO CHEMICAL CO (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5288682-A | Catalyst for asymmetric induction | SUMITOMO CHEMICAL CO., LTD. (JP) | 1994-02-22 | — | — | US | disclosed |
| EP-0505089-A1 | A catalyst for asymmetric induction | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-09-23 | — | — | EP | disclosed |
| EP-0458111-A1 | 1,6-dihydro-3-dimethylamino-4-methyl-1,2,4-triazine derivatives | BAYER AG (DE) | 1991-11-27 | — | — | EP | disclosed |
| US-4511562-A | (Thio)(dithio-phosphates(phosphonates), processes for their preparation, and their use in pest-combating agents | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-16 | — | — | US | disclosed |
| EP-0072482-A2 | (Thiono)(dithio)-phosphoric-(phosphonic)-acid esters, process for their preparation and their use as pesticides | BAYER AG (DE) | 1983-02-23 | — | — | EP | disclosed |
| US-4341789-A | ANTISECRETORY, ANTIAGGLOMERANTS, BRONCHODILATOR AND ANTIFERTILITY AGENTS | BEECHAM GROUP LIMITED (GB) | 1982-07-27 | — | — | US | disclosed |
| US-4201864-A | CHEMICAL INTERMEDIATES, PROSTAGLANDINS | BEECHAM GROUP LIMITED (GB) | 1980-05-06 | — | — | US | disclosed |
| US-4177283-A | ANTISECRETORY, ANTICOAGULANT, BRONCHODILATOR | BEECHAM GROUP LIMITED (GB) | 1979-12-04 | — | — | US | disclosed |
| US-4138407-A | ANTISECRETORY, BRONCHODILATOR, ANTICOAGULANT | BEECHAM GROUP LIMITED (GB) | 1979-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | TP53 363/4885KDM4E 2078/4885GMNN 3084/4885 |
| US-20210179600-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AS INHIBITORS OF ASK1 | IRAK1, IRAK2, IRAK3 | TP53 1185/4885KDM4E 2701/4885GMNN 4312/4885 |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | TYMS, TYMP, DPYD | TP53 22/4885KDM4E 2024/4885GMNN 696/4885 |
| US-20080200467-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | EPHX1, EPHX2, NCEH1 | TP53 3408/4885KDM4E 905/4885GMNN 2915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.