SCHEMBL3366023

SCHEMBL3366023

O=C(c1cccc2c1OCC2)C(Br)Br

nearest known ligand 0.66

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 6/20 0.66
HCRTR1 O43613 1/20 0.41
HCRTR2 O43614 1/20 0.41
MGLL Q99685 1/20 0.38
MAPT P10636 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
MAPK14 Q16539 1/20 0.38
RORC P51449 1/20 0.37
KCNA3 P22001 1/20 0.34
SSTR4 P31391 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13425738 0.88 PARP1 (0.62) PARP1HCRTR1HCRTR2MGLLMAPT
SCHEMBL25485607 0.84 PARP1 (0.66) PARP1HCRTR1HCRTR2MGLLNPSR1
SCHEMBL1502069 0.80 PARP1 (1.00) PARP1HCRTR1HCRTR2MGLLMAPT
SCHEMBL729580 0.80 PARP1 (0.74) PARP1HCRTR1HCRTR2MGLLMAPK14
SCHEMBL13425410 0.79 CTNNB1 (0.49) PARP1
SCHEMBL1021074 0.78 PARP1 (0.72) PARP1HCRTR1HCRTR2MGLLMAPT
SCHEMBL3360298 0.78 PARP1 (0.72) PARP1HCRTR1HCRTR2MGLLMAPT
Hydrochloric Acid SCHEMBL7265489 0.78 PARP1 (0.72) PARP1HCRTR1HCRTR2MGLLMAPK14
SCHEMBL31468360 0.78 PARP1 (0.57) PARP1HCRTR1HCRTR2MGLLMAPK14
SCHEMBL21804730 0.77 PARP1 (0.70) PARP1HCRTR1HCRTR2MGLLMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed