Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3369115 | 0.94 | HCRTR1 (0.52) | HCRTR1HCRTR2USP30DPP4AADAT | |
| SCHEMBL3368901 | 0.93 | HCRTR1 (0.51) | HCRTR1HCRTR2USP30DPP4ALDH1A1 | |
| SCHEMBL3370196 | 0.87 | HCRTR1 (0.56) | HCRTR1HCRTR2USP30ALDH1A1GRM5 | |
| SCHEMBL3370370 | 0.86 | HCRTR1 (0.60) | HCRTR1HCRTR2USP30DPP4HSD11B1 | |
| SCHEMBL3369795 | 0.84 | HCRTR1 (0.58) | HCRTR1HCRTR2USP30DPP4ALDH1A1 | |
| SCHEMBL18845562 | 0.84 | HCRTR1 (0.52) | HCRTR1HCRTR2USP30DPP4ALDH1A1 | |
| SCHEMBL3370192 | 0.84 | HCRTR1 (0.52) | HCRTR1HCRTR2USP30DPP4ALDH1A1 | |
| SCHEMBL3366778 | 0.83 | HCRTR1 (0.58) | HCRTR1HCRTR2USP30DPP4ALDH1A1 | |
| SCHEMBL3369475 | 0.83 | HCRTR1 (0.61) | HCRTR1HCRTR2USP30DPP4HSD11B1 | |
| SCHEMBL3366732 | 0.83 | HCRTR1 (0.52) | HCRTR1HCRTR2USP30DPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532141-B1 | 2-PYRROLIDIN-2-YL- [1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS | GRUENENTHAL GMBH (DE) | 2010-10-13 | — | — | EP | disclosed |