Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.91 |
| ▸ | KIT | P10721 | 1/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 2/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.69 |
| ▸ | ITK | Q08881 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17951509 | 0.95 | BTK (1.00) | BTKKITFLT3EGFRLCK | |
| SCHEMBL3362994 | 0.95 | BTK (1.00) | BTKKITFLT3EGFRLCK | |
| SCHEMBL13308556 | 0.91 | BTK (0.76) | BTKKITFLT3EGFRLCK | |
| SCHEMBL3361363 | 0.90 | BTK (0.78) | BTKKITFLT3EGFR | |
| SCHEMBL3361369 | 0.90 | BTK (0.78) | BTKKITFLT3EGFR | |
| SCHEMBL19590157 | 0.90 | BTK (0.80) | BTKKITFLT3EGFRLCK | |
| SCHEMBL30615729 | 0.90 | BTK (0.91) | BTKKITFLT3 | |
| SCHEMBL19638196 | 0.90 | BTK (0.91) | BTKKITFLT3 | |
| SCHEMBL19638194 | 0.90 | BTK (0.91) | BTKKITFLT3 | |
| SCHEMBL19649181 | 0.90 | BTK (0.91) | BTKKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741330-B1 | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS, INC. (US) | 2010-06-22 | — | — | US | disclosed |