Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.72 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367378 | 1.00 | GLA (0.78) | GLAHPGDFFAR1RAB9APOLB | |
| SCHEMBL3367373 | 0.88 | HPGD (0.68) | GLAHPGDRAB9APOLBNPC1 | |
| SCHEMBL3367368 | 0.88 | HPGD (0.68) | GLAHPGDRAB9APOLBNPC1 | |
| SCHEMBL3369207 | 0.88 | HPGD (0.88) | GLAHPGDFFAR1RAB9APOLB | |
| SCHEMBL3369202 | 0.88 | HPGD (0.88) | GLAHPGDFFAR1RAB9APOLB | |
| SCHEMBL5806905 | 0.88 | HPGD (0.88) | GLAHPGDFFAR1RAB9APOLB | |
| SCHEMBL3367994 | 0.87 | HPGD (0.61) | GLAHPGDRAB9APOLBNPC1 | |
| SCHEMBL3368001 | 0.87 | HPGD (0.61) | GLAHPGDRAB9APOLBNPC1 | |
| SCHEMBL5807686 | 0.87 | HPGD (0.69) | GLAHPGDFFAR1RAB9APOLB | |
| SCHEMBL3363939 | 0.85 | GLA (0.75) | GLAHPGDFFAR1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542970-B1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |
| US-7151111-B2 | 4-pyrrolidino-phenyl-benzyl ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-12-19 | — | — | US | disclosed |
| EP-1542970-A1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-06-22 | — | — | EP | disclosed |
| US-20040116707-A1 | 4-Pyrrolidino-phenyl-benzyl ether derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-17 | — | — | US | disclosed |
| WO-2004026825-A1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | disclosed |