Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367895 | 1.00 | KDM4E (0.63) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3844939 | 0.87 | KDM4E (0.46) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3844940 | 0.87 | KDM4E (0.46) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3371855 | 0.87 | KDM4E (0.61) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3371851 | 0.87 | KDM4E (0.61) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3402763 | 0.85 | KDM4E (0.59) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3402759 | 0.85 | KDM4E (0.59) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3373337 | 0.82 | KDM4E (0.48) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3373335 | 0.82 | KDM4E (0.48) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7257792 | 0.80 | KDM4E (0.65) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641792-B1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | NYCOMED GMBH (DE) | 2010-08-25 | — | — | EP | disclosed |
| EP-1641457-B1 | PYRROLO-DIHYDROISOQUINOLINE DERIVATIVES AS PDE10 INHIBITORS | NYCOMED GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| US-20070105840-A1 | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors | ALTANA PHARMA AG (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20060148840-A1 | Pyrrolodihydroisoquinolines as pde10 inhibitors | ALTANA PHARMA AG (DE) | 2006-07-06 | — | — | US | disclosed |
| EP-1641457-A1 | PYRROLO-DIHYDROISOQUINOLINE DERIVATIVES AS PDE10 INHIBITORS | ALTANA Pharma AG (DE) | 2006-04-05 | — | — | EP | disclosed |
| EP-1641792-A1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | ALTANA Pharma AG (DE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005002579-A1 | PYRROLO-DIHYDROISOQUINOLINE DERIVATIVES AS PDE10 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003129-A1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148840-A1 | Pyrrolodihydroisoquinolines as pde10 inhibitors | PDE12, PDE3A, PDE3B | KDM4E 269/4885LMNA 3392/4885ALDH1A1 848/4885 |
| US-20070105840-A1 | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors | PDE12, PDE2A, PDE5A | KDM4E 847/4885LMNA 2383/4885ALDH1A1 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.