Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 13/20 | 0.66 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.66 |
| ▸ | GRM5 | P41594 | 3/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370128 | 0.88 | HCRTR1 (0.59) | HCRTR1HCRTR2GRM5USP30MEN1 | |
| SCHEMBL3366901 | 0.88 | HCRTR1 (0.61) | HCRTR1HCRTR2GRM5USP30NPC1 | |
| SCHEMBL3366642 | 0.86 | HCRTR1 (0.58) | HCRTR1HCRTR2GRM5USP30MEN1 | |
| SCHEMBL3366959 | 0.84 | HCRTR1 (0.56) | HCRTR1HCRTR2USP30MEN1NPC1 | |
| SCHEMBL3369369 | 0.83 | HCRTR1 (0.60) | HCRTR1HCRTR2USP30 | |
| SCHEMBL3366195 | 0.83 | HCRTR1 (0.56) | HCRTR1HCRTR2USP30NPC1ALDH1A1 | |
| SCHEMBL3367896 | 0.82 | HCRTR1 (0.62) | HCRTR1HCRTR2USP30NPC1ALDH1A1 | |
| SCHEMBL3367597 | 0.82 | HCRTR1 (0.63) | HCRTR1HCRTR2USP30 | |
| SCHEMBL3370194 | 0.82 | GRM5 (0.60) | HCRTR1HCRTR2GRM5USP30 | |
| SCHEMBL3364202 | 0.82 | HCRTR1 (0.54) | HCRTR1HCRTR2GRM5USP30MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532141-B1 | 2-PYRROLIDIN-2-YL- [1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS | GRUENENTHAL GMBH (DE) | 2010-10-13 | — | — | EP | disclosed |