Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 12/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367009 | 0.91 | LSS (0.49) | LSSMEN1KMT2A | |
| SCHEMBL3368204 | 0.91 | LSS (0.49) | LSSALDH1A1MEN1KMT2A | |
| SCHEMBL3365080 | 0.90 | LSS (0.48) | LSSMEN1KMT2A | |
| SCHEMBL3367117 | 0.90 | LSS (0.60) | LSSLTA4HMEN1KMT2A | |
| SCHEMBL3368392 | 0.90 | LSS (0.56) | LSSLTA4HMEN1KMT2A | |
| SCHEMBL3368101 | 0.89 | LSS (0.55) | LSSLTA4HALDH1A1 | |
| SCHEMBL3367108 | 0.87 | LSS (0.59) | LSSALDH1A1MEN1KMT2A | |
| SCHEMBL3364796 | 0.86 | LSS (0.55) | LSSMEN1KMT2A | |
| SCHEMBL3364874 | 0.84 | LSS (0.49) | LSSALDH1A1MEN1KMT2A | |
| SCHEMBL3365207 | 0.84 | LSS (0.45) | LSSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |