Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370527 | 1.00 | NR1H2 (0.50) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 | |
| SCHEMBL3403168 | 1.00 | NR1H2 (0.50) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 | |
| SCHEMBL13068571 | 1.00 | NR1H2 (0.50) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 | |
| SCHEMBL13438547 | 0.87 | NR1H2 (0.44) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 | |
| SCHEMBL2937360 | 0.85 | NR1H2 (0.65) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 | |
| SCHEMBL1014216 | 0.85 | NR1H2 (0.65) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 | |
| SCHEMBL30721755 | 0.85 | NR1H2 (0.65) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 | |
| SCHEMBL2930155 | 0.85 | NR1H2 (0.65) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 | |
| SCHEMBL24392671 | 0.82 | NAMPT (0.52) | NR1H2NAMPTEPHX1ALDH1A1MAPT | |
| SCHEMBL13177251 | 0.82 | NR1H2 (0.39) | NR1H2PDE4BNAMPTEPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | disclosed |