⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14757680 | 0.78 | — | — | |
| SCHEMBL37098 | 0.78 | — | — | |
| SCHEMBL37097 | 0.78 | — | — | |
| SCHEMBL1249383 | 0.76 | HCAR2 (0.44) | — | |
| SCHEMBL10444878 | 0.76 | HCAR2 (0.44) | — | |
| SCHEMBL28910 | 0.75 | — | — | |
| SCHEMBL6833025 | 0.75 | — | — | |
| SCHEMBL1023871 | 0.75 | — | — | |
| SCHEMBL1530892 | 0.72 | — | — | |
| SCHEMBL1530891 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594854-B1 | THIAZOLYL-BASED COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2010-09-01 | — | — | EP | disclosed |
| US-7323482-B2 | Thiazolyl-based compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-29 | — | — | US | disclosed |
| EP-1594854-A4 | THIAZOLYL-BASED COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20070093537-A1 | Thiazolyl-based compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-26 | — | — | US | disclosed |
| US-7169771-B2 | Thiazolyl-based compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| EP-1594854-A2 | THIAZOLYL-BASED COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040220233-A1 | Thiazolyl-based compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-04 | — | — | US | disclosed |
| WO-2004071440-A2 | THIAZOLYL-BASED COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-08-26 | — | — | WO | disclosed |