(Z)-1,2-Diphenylethene

(Z)-1,2-Diphenylethene

SCHEMBL3373157

C(=Cc1ccccc1)c1ccccc1.C1CNCCN1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ESR1

The experimentally established mechanism targets of (Z)-1,2-Diphenylethene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.52
MAOA P21397 3/20 0.52
ADRA2A P08913 1/20 0.52
NISCH Q9Y2I1 1/20 0.52
NFE2L2 Q16236 2/20 0.50
CYP19A1 P11511 2/20 0.50
HDAC3 O15379 1/20 0.48
TNKS O95271 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HCAR2 Q8TDS4 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
TNKS2 Q9H2K2 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(Z)-1,2-Diphenylethene SCHEMBL3373155 1.00 MAOB (0.52) MAOBMAOAADRA2ANISCHNFE2L2
Piperazine SCHEMBL27617567 0.85 MAOB (0.44) MAOBMAOAADRA2ANISCHNFE2L2
Piperazine SCHEMBL27278329 0.84 MAOB (0.42) MAOBMAOAADRA2ANISCHNFE2L2
(Z)-1,2-Diphenylethene SCHEMBL443 0.82 MAOB (0.73) MAOBMAOANFE2L2CYP19A1HDAC3
(Z)-1,2-Diphenylethene SCHEMBL9134296 0.82 MAOB (0.73) MAOBMAOANFE2L2CYP19A1HDAC3
(Z)-1,2-Diphenylethene SCHEMBL9134305 0.82 MAOB (0.73) MAOBMAOANFE2L2CYP19A1HDAC3
(Z)-1,2-Diphenylethene SCHEMBL9488275 0.82 MAOB (0.73) MAOBMAOANFE2L2CYP19A1HDAC3
(Z)-1,2-Diphenylethene SCHEMBL21847984 0.82 MAOB (0.73) MAOBMAOANFE2L2CYP19A1HDAC3
(Z)-1,2-Diphenylethene SCHEMBL22712863 0.82 MAOB (0.73) MAOBMAOANFE2L2CYP19A1HDAC3
(Z)-1,2-Diphenylethene SCHEMBL9488270 0.82 MAOB (0.73) MAOBMAOANFE2L2CYP19A1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2236488-A1 Materials, methods and uses for photochemical generation of acids and/or radical species The Arizona Board of Regents on behalf of the University of Arizona (US) 2010-10-06 EP disclosed
US-7459106-B2 Materials, methods, and uses for photochemical generation of acids and/or radical species THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2008-12-02 US disclosed
EP-1390664-A4 MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES UNIV ARIZONA (US) 2008-01-02 EP disclosed
US-20050173683-A1 Materials, methods, and uses for photochemical generation of acids and/or radical species THE ARIZ BD OF REGENTS ON BEHALF OF THE UNIV OF AZ (US) 2005-08-11 US disclosed
EP-1390664-A1 MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES The Arizona Board of Regents (US) 2004-02-25 EP disclosed
WO-2002079691-A1 MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2002-10-10 WO disclosed