Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.46 |
| ▸ | PPARA | Q07869 | 15/20 | 0.46 |
| ▸ | PPARD | Q03181 | 3/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3373023 | 0.93 | PPARG (0.48) | PPARGPPARAPPARD | |
| SCHEMBL3371005 | 0.91 | PPARG (0.45) | PPARGPPARAPPARD | |
| SCHEMBL3369718 | 0.90 | PPARG (0.47) | PPARGPPARAPPARDRARARARB | |
| SCHEMBL3372687 | 0.90 | PPARG (0.46) | PPARGPPARAPPARD | |
| SCHEMBL3374331 | 0.89 | PPARG (0.41) | PPARGPPARAPPARD | |
| SCHEMBL3374455 | 0.86 | PPARG (0.49) | PPARGPPARAPPARD | |
| SCHEMBL3370559 | 0.84 | PPARG (0.47) | PPARGPPARAPPARD | |
| SCHEMBL3370565 | 0.83 | PPARG (0.49) | PPARGPPARAPPARDRARARARB | |
| SCHEMBL3373906 | 0.83 | MAPT (0.43) | PPARGPPARAPPARD | |
| SCHEMBL3371570 | 0.82 | PPARG (0.50) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537091-B1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |
| EP-1537091-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-06-08 | — | — | EP | disclosed |
| US-6809110-B2 | NONINSULIN DEPENDENT DIABETES; SUCH AS 2-ETHOXY-3-(4-(2-(5-METHYL-2-PHENYL-THIAZOL-4-YL)-ETHOXY)-BENZO(B)THIOPHEN-7-YL)-PROPIONIC ACID | HOFFMANN-LA ROCHE INC. | 2004-10-26 | — | — | US | disclosed |
| WO-2004020420-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-03-11 | — | — | WO | disclosed |