Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211895 | 0.70 | BRD4 (0.53) | BRD4CREBBPHTTCYP19A1CYP11B1 | |
| SCHEMBL2933275 | 0.69 | BRAF (0.41) | MAPK14BRAF | |
| SCHEMBL16536586 | 0.69 | PDE4A (0.53) | BRD4CREBBPCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL16537757 | 0.69 | PDE4A (0.53) | BRD4CREBBPCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL25366826 | 0.68 | HTT (0.42) | BRD4CREBBPHTTPOLBLMNA | |
| SCHEMBL16563587 | 0.68 | PDE3A (0.36) | BRD4CREBBPALDH1A1POLBLMNA | |
| SCHEMBL4894335 | 0.68 | BRD4 (0.50) | BRD4CREBBPHTTMEN1ALDH1A1 | |
| SCHEMBL6074738 | 0.67 | BRD4 (0.46) | BRD4CREBBPCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL22368749 | 0.67 | BRD4 (0.61) | BRD4CREBBPHTTTNKS2CYP19A1 | |
| SCHEMBL5546557 | 0.67 | BRD4 (0.46) | BRD4CREBBPHTTCYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |