Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.64 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.64 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.56 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 7/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | CHUK | O15111 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99743 | 0.99 | AURKB (0.63) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL29541367 | 0.99 | AURKB (0.63) | AURKBAURKAINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL4082148 | 0.89 | AURKA (0.52) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL30008948 | 0.88 | AURKB (0.64) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL101352 | 0.87 | AURKB (0.58) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL100434 | 0.86 | AURKB (0.59) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL16655062 | 0.84 | AURKB (0.57) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL27742089 | 0.84 | AURKB (0.57) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL100953 | 0.84 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL101092 | 0.83 | AURKB (0.56) | AURKBAURKAINCENPTPX2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013173506-A2 | METHOD OF TREATING MUSCULAR DEGRADATION | RIGEL PHARMACEUTICALS, INC. (US) | 2013-11-21 | — | — | WO | disclosed |
| WO-2010039939-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | INCYTE CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |