Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rosiglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 15/20 | 0.98 |
| ▸ | RXRA | P19793 | 2/20 | 0.86 |
| ▸ | RARG | P13631 | 1/20 | 0.86 |
| ▸ | PPARA | Q07869 | 2/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rosiglitazone SCHEMBL1489117 | 1.00 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3379945 | 0.99 | PPARG (0.96) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL5574033 | 0.99 | PPARG (0.96) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL1489291 | 0.99 | PPARG (0.96) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3379949 | 0.99 | PPARG (0.96) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL7052472 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL11957687 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL2355017 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL5169 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL29530259 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867343-A2 | Novel compounds | GLAXO GROUP LIMITED (GB) | 2007-12-19 | — | — | EP | claimed |
| US-7074811-B2 | Hydrochloride salts of 5-[4-[2-(n-methyl-n-(2-pyridyl) amino)ethoxy]benzyl]thiazolidine-2,4-dione | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-07-11 | — | — | US | claimed |
| US-20060094691-A1 | Inclusion complexes of rosiglitazone | GLAXO GROUP LIMITED (GB) | 2006-05-04 | — | — | US | claimed |
| US-20050267162-A1 | Hydrochloride salts of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione | SMITHKLINE BEECHAM PLC | 2005-12-01 | — | — | US | claimed |
| EP-1509249-A2 | INCLUSION COMPLEXES OF ROSIGLITAZONE | GLAXO GROUP LIMITED (GB) | 2005-03-02 | — | — | EP | claimed |
| WO-2003099337-A2 | INCLUSION COMPLEXES OF ROSIGLITAZONE | GLAXO GROUP LIMITED (GB) | 2003-12-04 | — | — | WO | claimed |
| CN-110627781-B | Novel rosiglitazone analogue and preparation method and application thereof | 江阴安博生物医药有限公司 | 2021-04-27 | — | — | CN | disclosed |
| CN-110627781-A | Novel rosiglitazone analogue and preparation method and application thereof | 江阴安博生物医药有限公司 | 2019-12-31 | — | — | CN | disclosed |
| EP-2021339-B1 | ROSIGLITAZONE HYDROCHLORIDE HEMIHYDRATE | SANDOZ AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| EP-2021339-A1 | ROSIGLITAZONE HYDROCHLORIDE HEMIHYDRATE | Sandoz AG (CH) | 2009-02-11 | — | — | EP | disclosed |
| EP-1867343-A2 | Novel compounds | GLAXO GROUP LIMITED (GB) | 2007-12-19 | — | — | EP | disclosed |
| EP-1842850-A1 | Rosiglitazone hydrochloride hemihydrate | Sandoz AG (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2007107354-A1 | ROSIGLITAZONE HYDROCHLORIDE HEMIHYDRATE | SANDOZ AG (CH) | 2007-09-27 | — | — | WO | disclosed |
| US-20020050563-A1 | Process for the preparation of pharmaceutically active thiazolidine or oxazolidine compounds by a yeast reductase | SMITHKLINE BEECHAM P.L.C. | 2002-05-02 | — | — | US | disclosed |
| WO-2002020519-A1 | THE HYDROCHLORIDE SALT OF 5-[4-[2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY]BENZYL]THIAZOLIDINE-2,4-DIONE | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-03-14 | — | — | WO | disclosed |
| WO-2001068646-A1 | HYDROCHLORIDE SALTS OF 5-[4-[2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY]BENZYL]THIAZOLIDINE-2,4-DIONE | SMITHKLINE BEECHAM PLC (GB) | 2001-09-20 | — | — | WO | disclosed |
| EP-0615549-B1 | PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACTIVE THIAZOLIDINE OR OXAZOLIDINE COMPOUNDS BY A YEAST REDUCTASE | SMITHKLINE BEECHAM PLC (GB) | 1999-06-09 | — | — | EP | disclosed |
| EP-0905255-A2 | Process for the preparation of pharmaceutically active thiazolidine or oxazolidine compounds by a yeast reductase | SMITHKLINE BEECHAM PLC (GB) | 1999-03-31 | — | — | EP | disclosed |
| EP-0615549-A1 | PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACTIVE THIAZOLIDINE OR OXAZOLIDINE COMPOUNDS BY A YEAST REDUCTASE | SMITHKLINE BEECHAM PLC (GB) | 1994-09-21 | — | — | EP | disclosed |
| WO-1993010254-A1 | PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACTIVE THIAZOLIDINE OR OXAZOLIDINE COMPOUNDS BY A YEAST REDUCTASE | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |