Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377329 | 0.88 | HRH3 (0.40) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3379864 | 0.88 | HRH3 (0.39) | HRH3CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL3376019 | 0.87 | HRH3 (0.42) | HRH3CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL3376806 | 0.84 | HRH3 (0.43) | HRH3MEN1KMT2APOLBKDM4E | |
| SCHEMBL3374996 | 0.84 | HRH3 (0.40) | HRH3OPRK1MEN1KMT2APOLB | |
| SCHEMBL3375023 | 0.84 | HRH3 (0.40) | HRH3MEN1KMT2APOLBKDM4E | |
| SCHEMBL3376004 | 0.84 | HRH3 (0.56) | HRH3MEN1KMT2APOLBKDM4E | |
| SCHEMBL3379308 | 0.83 | HRH3 (0.39) | HRH3KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL3377612 | 0.83 | MCHR1 (0.46) | HRH3MEN1KMT2APOLBKDM4E | |
| SCHEMBL3377924 | 0.83 | HRH3 (0.41) | HRH3CYP3A4CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |