Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1923273 | 1.00 | DRD3 (0.49) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL1923275 | 1.00 | DRD3 (0.49) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL1923651 | 1.00 | DRD3 (0.49) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL10086739 | 1.00 | DRD3 (0.49) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL337028 | 1.00 | DRD3 (0.49) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL1923274 | 1.00 | DRD3 (0.49) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL337608 | 0.97 | HTR2A (0.48) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL337609 | 0.97 | HTR2A (0.48) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL337607 | 0.97 | HTR2A (0.48) | DRD3HTR2ASMN1; SMN2LMNAHTT | |
| SCHEMBL336994 | 0.95 | HTR2A (0.53) | DRD3HTR2ASMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097637-B2 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2012-01-17 | — | — | US | claimed |
| EP-2185513-B1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2011-06-08 | — | — | EP | claimed |
| US-8097637-B2 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2012-01-17 | — | — | US | disclosed |
| EP-2185513-B1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2011-06-08 | — | — | EP | disclosed |