Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380456 | 0.94 | HRH3 (0.47) | HRH3KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL3376782 | 0.93 | HRH3 (0.46) | HRH3KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL3377335 | 0.86 | HRH3 (0.48) | HRH3KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL3378079 | 0.85 | HRH3 (0.48) | HRH3KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL3380891 | 0.83 | HRH3 (0.46) | HRH3KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL3378215 | 0.82 | CYP2A13 (0.39) | HRH3CYP2A13KDM4EALDH1A1POLB | |
| SCHEMBL3378015 | 0.82 | HRH3 (0.45) | HRH3KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL3376046 | 0.81 | HRH3 (0.44) | HRH3ALDH1A1POLBSOS1OPRM1 | |
| SCHEMBL3380045 | 0.81 | HRH3 (0.44) | HRH3KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL3375322 | 0.81 | HRH3 (0.44) | HRH3KDM4EALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |