Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | CCR3 | P51677 | 4/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380460 | 0.87 | KCNH2 (0.45) | HRH3KCNH2BCHEKMT2AADRB2 | |
| SCHEMBL3380259 | 0.87 | HRH3 (0.45) | HRH3KCNH2HRH1CCR3BCHE | |
| SCHEMBL3381173 | 0.85 | HRH3 (0.57) | HRH3KCNH2HRH1CCR3MLNR | |
| Cyclohexane SCHEMBL3380419 | 0.85 | HRH3 (0.57) | HRH3KCNH2HRH1CCR3MLNR | |
| Cyclopropane SCHEMBL3413689 | 0.85 | HRH3 (0.57) | HRH3KCNH2HRH1CCR3MLNR | |
| Cyclopentane SCHEMBL3381172 | 0.85 | HRH3 (0.57) | HRH3KCNH2HRH1CCR3MLNR | |
| SCHEMBL3377707 | 0.85 | HRH3 (0.55) | HRH3KCNH2HRH1CCR3MLNR | |
| SCHEMBL3380037 | 0.85 | HRH3 (0.38) | HRH3KCNH2HRH1CCR3BCHE | |
| SCHEMBL3375063 | 0.84 | HRH3 (0.70) | HRH3KCNH2HRH1CCR3MLNR | |
| SCHEMBL3377922 | 0.84 | HRH3 (0.54) | HRH3KCNH2HRH1CCR3MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |